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ACTIVATION OF ASK-1 AND DOWNSTREAM MAP KINASES IN CYTOCHROME P4502E1 POTENTIATED TUMOR NECROSIS FACTOR ALPHA LIVER INJURY
Cytochrome P4502E1 (CYP2E1) potentiated TNFα-toxicity by a mechanism involving increased oxidative stress and activation of JNK and p38 MAPKs. The current study evaluated what are the upstream mediators of this MAPK activation with a special focus on studying whether Apoptosis Signal Regulating Kina...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2900408/ https://ncbi.nlm.nih.gov/pubmed/20438834 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2010.04.021 |
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