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CYP2E1 Sensitizes the Liver to LPS- and TNF α-Induced Toxicity via Elevated Oxidative and Nitrosative Stress and Activation of ASK-1 and JNK Mitogen-Activated Kinases

The mechanisms by which alcohol causes cell injury are not clear. A major mechanism is the role of lipid peroxidation and oxidative stress in alcohol toxicity. Many pathways have been suggested to play a role in how alcohol induces oxidative stress. Considerable attention has been given to alcohol e...

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Detalhes bibliográficos
Main Authors: Cederbaum, Arthur I., Yang, Lili, Wang, Xiaodong, Wu, Defeng
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3199085/
https://ncbi.nlm.nih.gov/pubmed/22028977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2012/582790
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