Critical Role of CD4 Help in CD154 Blockade-Resistant Memory CD8 T Cell Activation and Allograft Rejection in Sensitized Recipients

Allograft rejection in sensitized recipients remains the major problem in clinical organ transplantation. We have developed a donor-type skin-sensitized mouse cardiac allograft model (BALB/c→C57BL/6) in which both rejection (<5 days) and alloreactive CD8 activation are resistant to CD154 blockade...

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Bibliographic Details
Main Authors: Wu, Zheng, Wang, Yue, Gao, Feng, Shen, Xiuda, Zhai, Yuan, Kupiec-Weglinski, Jerzy W.
Format: Artigo
Language:Inglês
Published: 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2975478/
https://ncbi.nlm.nih.gov/pubmed/18606661
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