The p53 target Plk2 interacts with TSC proteins impacting mTOR signaling, tumor growth and chemosensitivity under hypoxic conditions

Tuberous sclerosis complex 1 (TSC1) inhibits mammalian target of rapamycin (mTOR), a central promotor of cell growth and proliferation. The protein product of the TSC1 gene, hamartin (referred to as TSC1) is known to interact with Polo-like kinase 1 (Plk1) in a cell cycle regulated, phosphorylation-...

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Bibliografiske detaljer
Main Authors: Matthew, Elizabeth M., Hart, Lori S., Astrinidis, Aristotelis, Navaraj, Arunasalam, Dolloff, Nathan G., Dicker, David T., Henske, Elizabeth P., El-Deiry, Wafik S.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2975271/
https://ncbi.nlm.nih.gov/pubmed/20054236
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