Structural Studies of Inositol 1,4,5-Trisphosphate Receptor: COUPLING LIGAND BINDING TO CHANNEL GATING

The three isoforms of the inositol 1,4,5-trisphosphate receptor (IP(3)R) exhibit distinct IP(3) sensitivities and cooperativities in calcium (Ca(2+)) channel function. The determinants underlying this isoform-specific channel gating mechanism have been localized to the N-terminal suppressor region o...

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Detalhes bibliográficos
Main Authors: Chan, Jenny, Yamazaki, Haruka, Ishiyama, Noboru, Seo, Min-Duk, Mal, Tapas K., Michikawa, Takayuki, Mikoshiba, Katsuhiko, Ikura, Mitsuhiko
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2975231/
https://ncbi.nlm.nih.gov/pubmed/20843799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.140160
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