Mechanistic basis of bell-shaped dependence of inositol 1,4,5-trisphosphate receptor gating on cytosolic calcium

The inositol 1,4,5-trisphosphate (IP(3)) receptor (IP(3)R) is an intracellular Ca(2+) release channel, and its opening is controlled by IP(3) and Ca(2+). A single IP(3) binding site and multiple Ca(2+) binding sites exist on single subunits, but the precise nature of the interplay between these two...

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Bibliografiske detaljer
Main Authors: Shinohara, Tadashi, Michikawa, Takayuki, Enomoto, Masahiro, Goto, Jun-Ichi, Iwai, Miwako, Matsu-ura, Toru, Yamazaki, Haruka, Miyamoto, Akitoshi, Suzuki, Akio, Mikoshiba, Katsuhiko
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2011
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3174635/
https://ncbi.nlm.nih.gov/pubmed/21876165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1101677108
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