Nuclear Retention of Unspliced Pre-mRNAs by Mutant DHX16/hPRP2, a Spliceosomal DEAH-box Protein

Defective or imbalanced expression of spliceosomal factors has been linked to human disease; however, how a defective spliceosome affects intron-containing gene transcripts in human cells is largely unknown. DEAH-box protein DHX16 is a human orthologue of Saccharomyces cerevisiae spliceosomal protei...

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Detalhes bibliográficos
Main Authors: Gencheva, Marieta, Lin, Ting-Yu, Wu, Xiwei, Yang, Lixin, Richard, Caroline, Jones, Matthew, Lin, Shwu-Bin, Lin, Ren-Jang
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
RNA
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2975187/
https://ncbi.nlm.nih.gov/pubmed/20841358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.122309
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