An Interdomain Interaction of the Androgen Receptor Is Required for Its Aggregation and Toxicity in Spinal and Bulbar Muscular Atrophy

Polyglutamine expansion within the androgen receptor (AR) causes spinal and bulbar muscular atrophy (SBMA) and is associated with misfolded and aggregated species of the mutant AR. We showed previously that nuclear localization of the mutant AR was necessary but not sufficient for SBMA. Here we show...

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Detalhes bibliográficos
Main Authors: Orr, Christopher R., Montie, Heather L., Liu, Yuhong, Bolzoni, Elena, Jenkins, Shannon C., Wilson, Elizabeth M., Joseph, James D., McDonnell, Donald P., Merry, Diane E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2975181/
https://ncbi.nlm.nih.gov/pubmed/20826791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.146845
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