ARHI (DIRAS 3), an imprinted tumor suppressor gene, binds to importins, and blocks nuclear import process of cargo proteins

ARHI (DIRAS3) is an imprinted tumor suppressor gene whose expression is lost in the majority of breast and ovarian cancers. Unlike its homologs Ras and Rap, ARHI functions as a tumor suppressor. Our previous study showed that ARHI can interact with the transcriptional activator Stat3 and inhibit its...

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Main Authors: Huang, Shaoyi, Chang, In Soon, Lin, Wenbo, Ye, Wenduo, Luo, Robert Z., Lu, Zhen, Lu, Yiling, Zhang, Ke, Liao, Warren S-L., Tao, Tao, Bast, Robert C., Chen, Xiaomin, Yu, Yinhua
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2974631/
https://ncbi.nlm.nih.gov/pubmed/19435463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BSR20090008
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