RapGEF2 is essential for embryonic hematopoiesis but dispensable for adult hematopoiesis

RapGEF2 is one of many guanine nucleotide exchange factors (GEFs) that specifically activate Rap1. Here, we generated RapGEF2 conditional knockout mice and studied its role in embryogenesis and fetal as well as adult hematopoietic stem cell (HSC) regulation. RapGEF2 deficiency led to embryonic letha...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Satyanarayana, Ande, Gudmundsson, Kristbjorn Orri, Chen, Xiu, Coppola, Vincenzo, Tessarollo, Lino, Keller, Jonathan R., Hou, Steven X.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2010
Soggetti:
Hematopoiesis and Stem Cells
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2974602/
https://ncbi.nlm.nih.gov/pubmed/20595512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-01-262964
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi