Depletion of L3MBTL1 promotes the erythroid differentiation of human hematopoietic progenitor cells: possible role in 20q− polycythemia vera

L3MBTL1, the human homolog of the Drosophila L(3)MBT polycomb group tumor suppressor gene, is located on chromosome 20q12, within the common deleted region identified in patients with 20q deletion-associated polycythemia vera, myelodysplastic syndrome, and acute myeloid leukemia. L3MBTL1 is expresse...

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Main Authors: Perna, Fabiana, Gurvich, Nadia, Hoya-Arias, Ruben, Abdel-Wahab, Omar, Levine, Ross L., Asai, Takashi, Voza, Francesca, Menendez, Silvia, Wang, Lan, Liu, Fan, Zhao, Xinyang, Nimer, Stephen D.
Format: Artigo
Jezik:Inglês
Izdano: American Society of Hematology 2010
Teme:
Red Cells, Iron, and Erythropoiesis
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2974589/
https://ncbi.nlm.nih.gov/pubmed/20585043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-02-270611
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