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Relative Role of Genetic Complement Abnormalities in Sporadic and Familial aHUS and Their Impact on Clinical Phenotype

Background and objectives: Hemolytic uremic syndrome (HUS) is characterized by microangiopathic hemolytic anemia, thrombocytopenia, and renal impairment. Most childhood cases are caused by Shiga toxin–producing bacteria. The other form, atypical HUS (aHUS), accounts for 10% of cases and has a poor p...

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Main Authors: Noris, Marina, Caprioli, Jessica, Bresin, Elena, Mossali, Chiara, Pianetti, Gaia, Gamba, Sara, Daina, Erica, Fenili, Chiara, Castelletti, Federica, Sorosina, Annalisa, Piras, Rossella, Donadelli, Roberta, Maranta, Ramona, van der Meer, Irene, Conway, Edward M., Zipfel, Peter F., Goodship, Timothy H., Remuzzi, Giuseppe
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Nephrology 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2974386/
https://ncbi.nlm.nih.gov/pubmed/20595690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2215/CJN.02210310
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