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Parenteral Delivery of HPβCD: Effects on Drug-HSA Binding

It is thought that cyclodextrins, such as 2-hydroxypropyl-β-cyclodextrin (HPβCD), will at high concentration affect pharmacokinetics of drugs through competitive binding with plasma proteins. Albumin is the major component of plasma proteins responsible for plasma protein binding. The purpose of thi...

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Main Authors: Kurkov, Sergey V., Loftsson, Thorsteinn, Messner, Martin, Madden, Donna
Formato: Artigo
Idioma:Inglês
Publicado: Springer US 2010
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2974121/
https://ncbi.nlm.nih.gov/pubmed/20658211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12249-010-9482-0
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