Human-Specific Evolution and Adaptation Led to Major Qualitative Differences in the Variable Receptors of Human and Chimpanzee Natural Killer Cells

Natural killer (NK) cells serve essential functions in immunity and reproduction. Diversifying these functions within individuals and populations are rapidly-evolving interactions between highly polymorphic major histocompatibility complex (MHC) class I ligands and variable NK cell receptors. Specif...

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Bibliographic Details
Main Authors: Abi-Rached, Laurent, Moesta, Achim K., Rajalingam, Raja, Guethlein, Lisbeth A., Parham, Peter
Format: Artigo
Language:Inglês
Published: Public Library of Science 2010
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2973822/
https://ncbi.nlm.nih.gov/pubmed/21079681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1001192
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