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Co-evolution of Killer Cell Immunoglobulin-like Receptors with HLA-C to Become The Major Variable Regulators of Human NK cells
Interactions between HLA class I and killer cell immunoglobulin-like receptors (KIR) diversify human NK cell responses. Dominant KIR ligands are the C1 and C2 epitopes of MHC-C, a young locus restricted to humans and great apes. C1 and C1-specific KIR evolved first, being present in orangutan and fu...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3124317/ https://ncbi.nlm.nih.gov/pubmed/20805421 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1001494 |
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