Constitutively active calcineurin induces cardiac endoplasmic reticulum stress and protects against apoptosis that is mediated by α-crystallin-B

Cardiac-specific overexpression of a constitutively active form of calcineurin A (CNA) leads directly to cardiac hypertrophy in the CNA mouse model. Because cardiac hypertrophy is a prominent characteristic of many cardiomyopathies, we deduced that delineating the proteomic profile of ventricular ti...

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Detalhes bibliográficos
Main Authors: Bousette, Nicolas, Chugh, Shaan, Fong, Vincent, Isserlin, Ruth, Kim, Kyoung-Han, Volchuk, Allen, Backx, Peter H., Liu, Peter, Kislinger, Thomas, MacLennan, David H., Emili, Andrew, Gramolini, Anthony O.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2972971/
https://ncbi.nlm.nih.gov/pubmed/20937869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1013555107
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