Epoxyeicosatrienoic Acid Agonist Regulates Human Mesenchymal Stem Cell–Derived Adipocytes Through Activation of HO-1-pAKT Signaling and a Decrease in PPARγ

Human mesenchymal stem cells (MSCs) expressed substantial levels of CYP2J2, a major CYP450 involved in epoxyeicosatrienoic acid (EET) formation. MSCs synthesized significant levels of EETs (65.8 ± 5.8 pg/mg protein) and dihydroxyeicosatrienoic acids (DHETs) (15.83 ± 1.62 pg/mg protein), suggesting t...

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Détails bibliographiques
Auteurs principaux: Kim, Dong Hyun, Vanella, Luca, Inoue, Kazuyoshi, Burgess, Angela, Gotlinger, Katherine, Manthati, Vijaya Lingam, Koduru, Sreenivasulu Reddy, Zeldin, Darryl C., Falck, John R., Schwartzman, Michal L., Abraham, Nader G.
Format: Artigo
Langue:Inglês
Publié: Mary Ann Liebert, Inc. 2010
Sujets:
Original Research Reports
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2972407/
https://ncbi.nlm.nih.gov/pubmed/20412023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/scd.2010.0098
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