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Role of PI3Kδ and PI3Kγ in inflammatory arthritis and tissue localization of neutrophils
The p110δ isoform of class I phosphoinositide 3-kinase (PI3Ks) plays a major role in B cell receptor signaling, while its p110γ counterpart is thought to predominate in leukocyte chemotaxis. Consequently, emphasis has been placed on developing PI3Kγ selective inhibitors to treat disease states that...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2008
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2972192/ https://ncbi.nlm.nih.gov/pubmed/18412166 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.200838266 |
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