The Ras oncogene signals centrosome amplification in mammary epithelial cells through cyclin D1/Cdk4 and Nek2

Centrosome amplification (CA) contributes to carcinogenesis by generating aneuploidy. Elevated frequencies of CA in most benign breast lesions and primary tumors suggest a causative role for CA in breast cancers. Clearly, identifying which and how altered signal transduction pathways contribute to C...

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Detalhes bibliográficos
Main Authors: Zeng, X, Shaikh, FY, Harrison, MK, Adon, AM, Trimboli, AJ, Carroll, KA, Sharma, N, Timmers, C, Chodosh, LA, Leone, G, Saavedra, HI
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2972189/
https://ncbi.nlm.nih.gov/pubmed/20581865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2010.253
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