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Purine Restriction Induces Pronounced Translational Upregulation of the NT1 Adenosine/Pyrimidine Nucleoside Transporter in Leishmania major

Leishmania and other parasitic protozoa are unable to synthesize purines de novo and are reliant upon purine nucleoside and nucleobase transporters to import preformed purines from their hosts. To study the roles of the four purine permeases NT1-NT4 in Leishmania major, null mutants in each transpor...

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Detalhes bibliográficos
Main Authors: Ortiz, Diana, Valdés, Raquel, Sanchez, Marco A., Hayenga, Johanna, Elya, Carolyn, Detke, Siegfried, Landfear, Scott M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2971681/
https://ncbi.nlm.nih.gov/pubmed/20735779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2958.2010.07328.x
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