Cigarette Smoke Induces Nucleic-Acid Oxidation in Lung Fibroblasts

Oxidative stress is widely proposed as a pathogenic mechanism for chronic obstructive pulmonary disease (COPD), but the molecular pathway connecting oxidative damage to tissue destruction remains to be fully defined. We suggest that reactive oxygen species (ROS) oxidatively damage nucleic acids, and...

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Hauptverfasser: Deslee, Gaetan, Adair-Kirk, Tracy L., Betsuyaku, Tomoko, Woods, Jason C., Moore, Carla H., Gierada, David S., Conradi, Susan H., Atkinson, Jeffrey J., Toennies, Holly M., Battaile, John T., Kobayashi, Dale K., Patterson, G. Alexander, Holtzman, Michael J., Pierce, Richard A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Thoracic Society 2010
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2970854/
https://ncbi.nlm.nih.gov/pubmed/20008282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2009-0221OC
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