Specific T Cell Frequency and Cytokine Expression Profile Do Not Correlate with Protection against Tuberculosis after Bacillus Calmette-Guérin Vaccination of Newborns

Rationale: Immunogenicity of new tuberculosis (TB) vaccines is commonly assessed by measuring the frequency and cytokine expression profile of T cells. Objectives: We tested whether this outcome correlates with protection against childhood TB disease after newborn vaccination with bacillus Calmette-...

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Main Authors: Kagina, Benjamin M. N., Abel, Brian, Scriba, Thomas J., Hughes, Elizabeth J., Keyser, Alana, Soares, Andreia, Gamieldien, Hoyam, Sidibana, Mzwandile, Hatherill, Mark, Gelderbloem, Sebastian, Mahomed, Hassan, Hawkridge, Anthony, Hussey, Gregory, Kaplan, Gilla, Hanekom, Willem A.
Format: Artigo
Sprog:Inglês
Udgivet: American Thoracic Society 2010
Fag:
E. Tuberculosis and Mycobacterial Disease
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2970848/
https://ncbi.nlm.nih.gov/pubmed/20558627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.201003-0334OC
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