Alternative Cyclin D1 Splice Forms Differentially Regulate the DNA Damage Response

The DNA damage response (DDR) activates downstream pathways including cell cycle checkpoints. The cyclin D1 gene is overexpressed or amplified in many human cancers and is required for gastrointestinal, breast, and skin tumors in murine models. A common polymorphism in the human cyclin D1 gene is al...

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Bibliografiske detaljer
Main Authors: Li, Zhiping, Jiao, Xuanmao, Wang, Chenguang, Shirley, L. Andrew, Elsaleh, Hany, Dahl, Olav, Wang, Min, Soutoglou, Evi, Knudsen, Erik S., Pestell, Richard G.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2970762/
https://ncbi.nlm.nih.gov/pubmed/20940395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-0312
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