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Cdc42 Interacting Protein 4 promotes breast cancer cell invasion and formation of invadopodia through activation of N-WASp

In the earliest stages of metastasis, breast cancer cells must reorganize the cytoskeleton to affect cell shape change and promote cell invasion and motility. These events require the cytoskeletal regulators Cdc42 and Rho, their effectors, such as N-WASp/WAVE, and direct inducers of actin polymeriza...

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Main Authors: Pichot, Christina S., Arvanitis, Constadina, Hartig, Sean M., Jensen, Samuel A., Bechill, John, Marzouk, Saad, Yu, Jindan, Frost, Jeffrey A., Corey, Seth J.
Formato: Artigo
Idioma:Inglês
Publicado: 2010
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2970640/
https://ncbi.nlm.nih.gov/pubmed/20940394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-4149
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