PPARγ Downregulation by TGFß in Fibroblast and Impaired Expression and Function in Systemic Sclerosis: A Novel Mechanism for Progressive Fibrogenesis

The nuclear orphan receptor peroxisome proliferator-activated receptor-gamma (PPAR-γ) is expressed in multiple cell types in addition to adipocytes. Upon its activation by natural ligands such as fatty acids and eicosanoids, or by synthetic agonists such as rosiglitazone, PPAR-γ regulates adipogenes...

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Autores principales: Wei, Jun, Ghosh, Asish K., Sargent, Jennifer L., Komura, Kazuhiro, Wu, Minghua, Huang, Qi-Quan, Jain, Manu, Whitfield, Michael L., Feghali-Bostwick, Carol, Varga, John
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2010
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2970611/
https://ncbi.nlm.nih.gov/pubmed/21072170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0013778
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