A synthetic PPAR-γ agonist triterpenoid ameliorates experimental fibrosis: PPAR-γ-independent suppression of fibrotic responses

BACKGROUND: Persistent fibroblast activation initiated by transforming growth factor β (TGF-β) is a fundamental event in the pathogenesis of systemic sclerosis (SSc), and its pharmacological inhibition represents a potential therapeutic strategy. The nuclear receptor peroxisome proliferator-activate...

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Hlavní autoři: Wei, Jun, Zhu, Hongyan, Komura, Kazuhiro, Lord, Gabriel, Tomcik, Michal, Wang, Wenxia, Doniparthi, Sruthi, Tamaki, Zenshiro, Hinchcliff, Monique, Distler, Joerg H. W., Varga, John
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4028127/
https://ncbi.nlm.nih.gov/pubmed/23515440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/annrheumdis-2012-202716
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