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Reduced Diabetes in btk-Deficient Nonobese Diabetic Mice and Restoration of Diabetes with Provision of an Anti-Insulin IgH Chain Transgene

Type 1 diabetes results from T cell-mediated destruction of insulin-producing β cells. Although elimination of B lymphocytes has proven successful at preventing disease, modulation of B cell function as a means to prevent type 1 diabetes has not been investigated. The development, fate, and function...

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Main Authors: Kendall, Peggy L., Moore, Daniel J., Hulbert, Chrys, Hoek, Kristen L., Khan, Wasif N., Thomas, James W.
Formato: Artigo
Idioma:Inglês
Publicado: 2009
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2970569/
https://ncbi.nlm.nih.gov/pubmed/19841184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0900367
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