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N-Methylated Cyclic Enkephalin Analogues Retain High Opioid Receptor Binding Affinity
In an effort to improve the bioavailability of the non-selective, cyclic enkephalin analogues H-Dmt-c[D-Cys-Gly-Phe-D(or L)-Cys]NH(2) (Dmt = 2′,6′-dimethyltyrosine), analogues N-methylated at the Phe(4) and/or Cys(5) residue were synthesized. In comparison with the non-methylated parent peptides, al...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2970513/ https://ncbi.nlm.nih.gov/pubmed/20028398 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1747-0285.2009.00919.x |
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