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N-Methylated Cyclic Enkephalin Analogues Retain High Opioid Receptor Binding Affinity

In an effort to improve the bioavailability of the non-selective, cyclic enkephalin analogues H-Dmt-c[D-Cys-Gly-Phe-D(or L)-Cys]NH(2) (Dmt = 2′,6′-dimethyltyrosine), analogues N-methylated at the Phe(4) and/or Cys(5) residue were synthesized. In comparison with the non-methylated parent peptides, al...

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Autors principals: Weltrowska, Grazyna, Berezowska, Irena, Lemieux, Carole, Chung, Nga N., Wilkes, Brian C., Schiller, Peter W.
Format: Artigo
Idioma:Inglês
Publicat: 2009
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2970513/
https://ncbi.nlm.nih.gov/pubmed/20028398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1747-0285.2009.00919.x
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