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Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene
Malignant cells often display defects in autophagy, an evolutionarily conserved pathway for degrading long-lived proteins and cytoplasmic organelles. However, as yet, there is no genetic evidence for a role of autophagy genes in tumor suppression. The beclin 1 autophagy gene is monoallelically delet...
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| Main Authors: | , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Society for Clinical Investigation
2003
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC297002/ https://ncbi.nlm.nih.gov/pubmed/14638851 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200320039 |
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