Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene

Malignant cells often display defects in autophagy, an evolutionarily conserved pathway for degrading long-lived proteins and cytoplasmic organelles. However, as yet, there is no genetic evidence for a role of autophagy genes in tumor suppression. The beclin 1 autophagy gene is monoallelically delet...

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Autori principali: Qu, Xueping, Yu, Jie, Bhagat, Govind, Furuya, Norihiko, Hibshoosh, Hanina, Troxel, Andrea, Rosen, Jeffrey, Eskelinen, Eeva-Liisa, Mizushima, Noboru, Ohsumi, Yoshinori, Cattoretti, Giorgio, Levine, Beth
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2003
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC297002/
https://ncbi.nlm.nih.gov/pubmed/14638851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200320039
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