Tumor necrosis factor-alpha and interferon-gamma suppress the activation of human type I collagen gene expression by transforming growth factor-beta 1. Evidence for two distinct mechanisms of inhibition at the transcriptional and posttranscriptional levels.
Regulation of human type I procollagen gene expression was studied in cultured fibroblasts both at the transcriptional and posttranscriptional level. Transcriptional regulation was examined in cultures transfected with a human pro alpha 2(I) collagen promoter/reporter gene (chloramphenicol acetyltra...
Furkejuvvon:
| Publikašuvnnas: | J Clin Invest |
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| Váldodahkkit: | , , , , |
| Materiálatiipa: | Artigo |
| Giella: | Inglês |
| Almmustuhtton: |
American Society for Clinical Investigation
1990
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| Fáttát: | |
| Liŋkkat: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC296894/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2122979/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI114866 |
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