Tumor necrosis factor-alpha and interferon-gamma suppress the activation of human type I collagen gene expression by transforming growth factor-beta 1. Evidence for two distinct mechanisms of inhibition at the transcriptional and posttranscriptional levels.

Regulation of human type I procollagen gene expression was studied in cultured fibroblasts both at the transcriptional and posttranscriptional level. Transcriptional regulation was examined in cultures transfected with a human pro alpha 2(I) collagen promoter/reporter gene (chloramphenicol acetyltra...

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Veröffentlicht in:	J Clin Invest
Hauptverfasser:	Kähäri, V M, Chen, Y Q, Su, M W, Ramirez, F, Uitto, J
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Clinical Investigation 1990
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC296894/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2122979/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI114866
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