Tumor necrosis factor-alpha and interferon-gamma suppress the activation of human type I collagen gene expression by transforming growth factor-beta 1. Evidence for two distinct mechanisms of inhibition at the transcriptional and posttranscriptional levels.
Regulation of human type I procollagen gene expression was studied in cultured fibroblasts both at the transcriptional and posttranscriptional level. Transcriptional regulation was examined in cultures transfected with a human pro alpha 2(I) collagen promoter/reporter gene (chloramphenicol acetyltra...
Sparad:
| I publikationen: | J Clin Invest |
|---|---|
| Huvudupphov: | , , , , |
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Utgiven: |
American Society for Clinical Investigation
1990
|
| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC296894/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2122979/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI114866 |
| Taggar: |
Inga taggar, Lägg till första taggen!
|