Possible role of bacterial siderophores in inflammation. Iron bound to the Pseudomonas siderophore pyochelin can function as a hydroxyl radical catalyst.

Tissue injury has been linked to neutrophil associated hydroxyl radical (.OH) generation, a process that requires an exogenous transition metal catalyst such as iron. In vivo most iron is bound in a noncatalytic form. To obtain iron required for growth, many bacteria secrete iron chelators (sideroph...

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Bibliografische gegevens

Gepubliceerd in:	J Clin Invest
Hoofdauteurs:	Coffman, T J, Cox, C D, Edeker, B L, Britigan, B E
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	American Society for Clinical Investigation 1990
Onderwerpen:	Research Article
Online toegang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC296829/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2170442/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI114805
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