Effect of 2′-O-methyl antisense ORNs on expression of thymidylate synthase in human colon cancer RKO cells

Translation of thymidylate synthase (TS) mRNA is controlled by its own protein end-product TS in a negative autoregulatory manner. Disruption of this regulation results in increased synthesis of TS and may lead to the development of cellular drug resistance to TS-directed anticancer agents. As a str...

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Detalhes bibliográficos

Publicado no:	Nucleic Acids Res
Principais autores:	Schmitz, John C., Yu, Dong, Agrawal, Sudhir, Chu, Edward
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Oxford University Press 2001
Assuntos:	Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC29681/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11139611/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/29.2.415
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