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Analysis of a Hand1 hypomorphic allele reveals a critical threshold for embryonic viability
Loss-of-function analysis of the bHLH transcription factor Hand1 indicates critical roles in development. In an effort to generate a Hand1 cDNA knock-in reporter mouse, we generated two hypomorphic alleles, which extend embryonic survival to between E10.5 and E12.5. Heart morphogenesis appears large...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2967597/ https://ncbi.nlm.nih.gov/pubmed/20737509 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/dvdy.22402 |
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