Biphasic role of 4-1BB in the regulation of mouse cytomegalovirus-specific CD8(+) T cells

The initial requirement for the emergence of CMV-specific CD8(+) T cells is poorly understood. Mice deficient in the cosignaling TNF superfamily member, 4-1BB, surprisingly developed exaggerated early CD8(+) T-cell responses to mouse CMV (MCMV). CD8(+) T cells directed against acute MCMV epitopes we...

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Bibliografiske detaljer
Main Authors: Humphreys, Ian R, Lee, Seung-Woo, Jones, Morgan, Loewendorf, Andrea, Gostick, Emma, Price, David A, Benedict, Chris A, Ware, Carl F, Croft, Michael
Format: Artigo
Sprog:Inglês
Udgivet: WILEY-VCH Verlag 2010
Fag:
Immunity to Infection
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2967573/
https://ncbi.nlm.nih.gov/pubmed/20722077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.200940256
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