Dasatinib reduces FAK phosphorylation increasing the effects of RPI-1 inhibition in a RET/PTC1-expressing cell line

BACKGROUND: TPC-1 is a papillary thyroid carcinoma (PTC)-derived cell line that spontaneously expresses the oncogene RET/PTC1. TPC-1 treated with the RET/PTC1 inhibitor RPI-1 displayed a cytostatic and reversible inhibition of cell proliferation and a strong activation of focal adhesion kinase (FAK)...

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Hauptverfasser: Caccia, Dario, Miccichè, Francesca, Cassinelli, Giuliana, Mondellini, Piera, Casalini, Patrizia, Bongarzone, Italia
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2010
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2967544/
https://ncbi.nlm.nih.gov/pubmed/20955590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-9-278
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