RET/PTC1-Driven Neoplastic Transformation and Proinvasive Phenotype of Human Thyrocytes Involve Met Induction and β-Catenin Nuclear Translocation

Activation of the RET gene by chromosomal rearrangements generating RET/PTC oncogenes is a frequent, early, and causative event in papillary thyroid carcinoma (PTC). We have previously shown that, in human primary thyrocytes, RET/PTC1 induces a transcriptional program including the MET proto-oncogen...

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Main Authors: Cassinelli, Giuliana, Favini, Enrica, Degl'Innocenti, Debora, Salvi, Alessandro, De Petro, Giuseppina, Pierotti, Marco A, Zunino, Franco, Borrello, Maria Grazia, Lanzi, Cinzia
Format: Artigo
Language:Inglês
Published: Neoplasia Press Inc. 2009
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2606114/
https://ncbi.nlm.nih.gov/pubmed/19107227
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