Synergistic epigenetic reactivation of estrogen receptor-α (ERα) by combined green tea polyphenol and histone deacetylase inhibitor in ERα-negative breast cancer cells

BACKGROUND: The status of estrogen receptor-α (ERα) is critical to the clinical prognosis and therapeutic approach in breast cancer. ERα-negative breast cancer is clinically aggressive and has a poor prognosis because of the lack of hormone target-directed therapies. Previous studies have shown that...

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Autores principales: Li, Yuanyuan, Yuan, Yih-Ying, Meeran, Syed M, Tollefsbol, Trygve O
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2010
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2967543/
https://ncbi.nlm.nih.gov/pubmed/20946668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-9-274
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