Epigenetic reactivation of p21(CIP1/WAF1) and KLOTHO by a combination of bioactive dietary supplements is partially ERα-dependent in ERα-negative human breast cancer cells

Available treatment strategies against estrogen receptor (ER)-negative breast cancer patients are limited due to their poor response to hormonal therapy. We have shown previously that the combinations of green tea polyphenols (GTPs), a dietary DNA methyltransferase inhibitor, and sulforaphane (SFN),...

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Veröffentlicht in:Mol Cell Endocrinol
Hauptverfasser: Sinha, Sonam, Shukla, Samriddhi, Khan, Sajid, Tollefsbol, Trygve O., Meeran, Syed M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5132185/
https://ncbi.nlm.nih.gov/pubmed/25725373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mce.2015.02.020
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