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Molecular analysis of insertion/deletion mutations in protein 4.1 in elliptocytosis. I. Biochemical identification of rearrangements in the spectrin/actin binding domain and functional characterizations.

Protein 4.1 (80 kD) interacts with spectrin and short actin filaments to form the erythrocyte membrane skeleton. Mutations of spectrin and protein 4.1 are associated with elliptocytosis or spherocytosis and anemia of varying severity. We analyzed two mutant protein 4.1 molecules associated with elli...

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書誌詳細
出版年:J Clin Invest
主要な著者: Marchesi, S L, Conboy, J, Agre, P, Letsinger, J T, Marchesi, V T, Speicher, D W, Mohandas, N
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Clinical Investigation 1990
主題:
オンライン・アクセス:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC296754/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2384597/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI114738
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