Molecular analysis of insertion/deletion mutations in protein 4.1 in elliptocytosis. I. Biochemical identification of rearrangements in the spectrin/actin binding domain and functional characterizations.

Protein 4.1 (80 kD) interacts with spectrin and short actin filaments to form the erythrocyte membrane skeleton. Mutations of spectrin and protein 4.1 are associated with elliptocytosis or spherocytosis and anemia of varying severity. We analyzed two mutant protein 4.1 molecules associated with elli...

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發表在:	J Clin Invest
Principais autores:	Marchesi, S L, Conboy, J, Agre, P, Letsinger, J T, Marchesi, V T, Speicher, D W, Mohandas, N
格式:	Artigo
語言:	Inglês
出版:	American Society for Clinical Investigation 1990
主題:	Research Article
在線閱讀:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC296754/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2384597/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI114738
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