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DNA POLYMERASE β CATALYZED-PCNA INDEPENDENT LONG PATCH BASE EXCISION REPAIR SYNTHESIS: A MECHANISM FOR REPAIR OF OXIDATIVELY DAMAGED DNA ENDS IN POSTMITOTIC BRAIN
Oxidative DNA damage incidental to normal respiratory metabolism poses a particular threat to genomes of highly metabolic-long lived cells. We show that postmitotic brain has capacity to repair oxidatively damaged DNA ends, which are targets of the long patch (LP) base excision repair (BER) sub-path...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2967482/ https://ncbi.nlm.nih.gov/pubmed/18752643 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1471-4159.2008.05644.x |
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