In CD28-costimulated human naïve CD4(+) T cells, I-κB kinase controls the expression of cell cycle regulatory proteins via interleukin-2-independent mechanisms

Stimulation of naïve CD4(+) T cells through engagement of the T-cell receptor (TCR) and the CD28 co-receptor initiates cell proliferation which critically depends on interleukin (IL)-2 secretion and subsequent autocrine signalling via the IL-2 receptor. However, several studies indicate that in CD28...

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Bibliografiske detaljer
Main Authors: Lupino, Elisa, Buccinnà, Barbara, Ramondetti, Cristina, Lomartire, Annarosa, De Marco, Giovanni, Ricotti, Emanuela, Tovo, Pier-Angelo, Rinaudo, Maria T, Piccinini, Marco
Format: Artigo
Sprog:Inglês
Udgivet: Blackwell Science Inc 2010
Fag:
Original Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2967269/
https://ncbi.nlm.nih.gov/pubmed/20465575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2567.2010.03297.x
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