Development of Sporadic Microsatellite Instability in Colorectal Tumors Involves Hypermethylation at Methylated-In-Tumor Loci in Adenoma

Microsatellite instability (MSI) and genomic hypermethylation of methylated-in-tumor (MINT) loci are both strong prognostic indicators in a subgroup of patients with sporadic colorectal cancer (CRC). The present study was designed to determine whether the methylation of MINT loci during the progress...

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Hlavní autoři: de Maat, Michiel F.G., Narita, Norihiko, Benard, Anne, Yoshimura, Tetsunori, Kuo, Christine, Tollenaar, Rob A.E.M., de Miranda, Noel F.C.C., Turner, Roderick R., van de Velde, Cornelis J.H., Morreau, Hans, Hoon, Dave S.B.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Investigative Pathology 2010
Témata:
Regular Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2966793/
https://ncbi.nlm.nih.gov/pubmed/20952593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2010.091103
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