High Expression of Sphingosine 1-Phosphate Receptors, S1P(1) and S1P(3), Sphingosine Kinase 1, and Extracellular Signal-Regulated Kinase-1/2 Is Associated with Development of Tamoxifen Resistance in Estrogen Receptor-Positive Breast Cancer Patients

Various studies in cell lines have previously demonstrated that sphingosine kinase 1 (SK1) and extracellular signal-regulated kinase 1/2 (ERK-1/2) interact in an estrogen receptor (ER)-dependent manner to influence both breast cancer cell growth and migration. A cohort of 304 ER-positive breast canc...

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Bibliographic Details
Main Authors: Watson, Carol, Long, Jaclyn S., Orange, Clare, Tannahill, Claire L., Mallon, Elizabeth, McGlynn, Liane M., Pyne, Susan, Pyne, Nigel J., Edwards, Joanne
Format: Artigo
Language:Inglês
Published: American Society for Investigative Pathology 2010
Subjects:
Regular Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2966780/
https://ncbi.nlm.nih.gov/pubmed/20889557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2010.100220
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