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One-Pot Three-Step Synthesis of 1,2,3-Triazoles by Copper-Catalyzed Cycloaddition of Azides with Alkynes formed by a Sonogashira Cross-Coupling and Desilylation

[Image: see text] A microwave-assisted one-pot, three-step Sonogashira cross coupling-desilylation-cycloaddition sequence was developed for the convenient preparation of 1,4-disubstituted 1,2,3-triazoles starting from a range of halides, acyl chlorides, ethynyltrimethylsilane and azides.

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Bibliografiske detaljer
Main Authors: Friscourt, Frédéric, Boons, Geert-Jan
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2966525/
https://ncbi.nlm.nih.gov/pubmed/20942390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol1022036
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