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Rap1A regulates generation of T regulatory cells via LFA-1-dependent and LFA-1-independent mechanisms

The small GTPase Rap1A has a critical role in regulating cell-matrix and cell-cell adhesion. In T lymphocytes, Rap1A mediates LFA-1 activation and LFA-1-mediated adhesion. LFA-1 reduces the threshold of TCR signals for low affinity ligands. Previously, we determined that mice expressing constitutive...

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書誌詳細
主要な著者: Li, Lequn, Kim, Jin sub, Boussiotis, Vassiliki A.
フォーマット: Artigo
言語:Inglês
出版事項: 2010
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2966523/
https://ncbi.nlm.nih.gov/pubmed/20864093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellimm.2010.08.014
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