Redox Regulation of Lipopolysaccharide-mediated Sulfiredoxin Induction, Which Depends on Both AP-1 and Nrf2

Sulfiredoxin (Srx) is an enzyme that catalyzes the reduction of cysteine sulfinic acid of hyperoxidized peroxiredoxins and exerts a protective antioxidant role. Here we investigated the regulatory mechanism of Srx induction by lipopolysaccharide (LPS) in mouse macrophages. LPS up-regulated Srx expre...

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Main Authors: Kim, Hojin, Jung, Yuyeon, Shin, Bong Soo, Kim, Hyeryeon, Song, Hyunsook, Bae, Soo Han, Rhee, Sue Goo, Jeong, Woojin
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Signal Transduction
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2966056/
https://ncbi.nlm.nih.gov/pubmed/20826812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.126839
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